Helmius G
Ups J Med Sci Suppl. 1980;29:1-28.
An experimental method for induction of myocardial infarction in sheep is described. This leads to local infarction without arteriographically demonstrable lesions in the coronary arteries. A 0.95 mm thick thermosonde is introduced into a coronary artery through a catheter. The tip of the thermosonde is heated to 45-65 degrees C for 1-2 min and the thermosonde is then removed. On heating of the tip, infarction occurs instantaneously, as observed both macro- and microscopically and at left ventricular angiography. The thermosonde method described makes it possible to induce myocardial infarction in sheep in a reproducible way and is therefore applicable to studies of the pathogenesis of infarction. This justifies its use in investigations of the effect of myocardial infarction on the anatomy and function of the left ventricle and coronary arteries.
本文描述了一种在绵羊身上诱导心肌梗死的实验方法。该方法可导致局部梗死，而冠状动脉造影未显示病变。通过导管将一根0.95毫米厚的热探头插入冠状动脉。将热探头尖端加热至45 - 65摄氏度，持续1 - 2分钟，然后取出热探头。加热探头尖端时，梗死即刻发生，这在大体和显微镜观察以及左心室血管造影中均有发现。所描述的热探头方法能够以可重复的方式在绵羊身上诱导心肌梗死，因此适用于梗死发病机制的研究。这证明了其在研究心肌梗死对左心室和冠状动脉的解剖结构及功能影响方面的应用价值。
