Maricq H R, Weinrich M C
Acta Psychiatr Scand. 1980 Mar;61(3):185-208. doi: 10.1111/j.1600-0447.1980.tb00869.x.
Psychophysiological studies in schizophrenics have generally resulted in contradictory and inconclusive reports. The purpose of the present study was to determine whether a better psychophysiological separation of schizophrenic and control subjects could be accomplished by selecting them on the basis of a biological marker: the high plexus visualization score (PVS). Finger blood flow, skin temperature and electrodermal recovery rates were studied in 64 male schizophrenics (33 high PVS and 31 low PVS) and 24 male controls (10 high PVS and 14 low PVS) matched for age. All control subjects and 30 of the schizophrenics (16 high PVS and 14 low PVS) had been drug-free for at least 1 month. They were studied in a sound attenuated, temperature controlled room under 12 experimental conditions. The results demonstrate that, as predicted, schizophrenics with high PVS have the lowest finger blood flow rates, the lowest skin temperatures and the slowest GSR recovery rates of all groups studied. The largest difference in all three variables was found between high PVS schizophrenics and high PVS controls. The blood flow rates and the skin temperature were higher and the electrodermal responses were fewer in patients taking medications than in those receiving placebos. A suggestion of a bimodal distribution into "responders" and "non-responders" was apparent only in patients receiving medications.
对精神分裂症患者进行的心理生理学研究通常得出相互矛盾且无定论的报告。本研究的目的是确定能否通过基于一种生物学标志物：高丛可视化评分（PVS）来选择精神分裂症患者和对照受试者，从而实现更好的心理生理学区分。对64名男性精神分裂症患者（33名高PVS和31名低PVS）以及24名年龄匹配的男性对照者（10名高PVS和14名低PVS）的手指血流量、皮肤温度和皮肤电反应恢复率进行了研究。所有对照受试者以及30名精神分裂症患者（16名高PVS和14名低PVS）已至少1个月未服用药物。他们在一个隔音、温度受控的房间里，在12种实验条件下接受研究。结果表明，正如所预测的，高PVS的精神分裂症患者在所有研究组中手指血流量最低、皮肤温度最低且皮肤电反应恢复率最慢。在高PVS精神分裂症患者和高PVS对照者之间，所有这三个变量的差异最大。服用药物的患者的血流量和皮肤温度高于服用安慰剂的患者，且皮肤电反应较少。仅在服用药物的患者中明显存在一种分为“反应者”和“无反应者”的双峰分布迹象。
