Meister P, Konrad E A, Wallmüller-Strycker A
Arch Orthop Trauma Surg (1978). 1980;96(1):75-8. doi: 10.1007/BF01246148.
This was the case of a 64-year-old man with osteosarcoma. The biopsy yielded undifferentiated tumor without bone or cartilage formation. Because of high age of the patient and radiological changes present, a metastatic carcinoma was suspected. However, no primary could be found. Autopsy revealed an osteosarcoma in the region of the hip joint with alternating formation of tumor cartilage and tumor bone. There were also undifferentiated portions of "endocrine osteosarcoma," simulating carcinoma. In spite of extensive skeletal involvement and pulmonary metastases--and high age--no evidence of morbus Paget of bone as possible preneoplastic disease was found.
这是一名64岁骨肉瘤男性患者的病例。活检结果显示为未分化肿瘤,无骨或软骨形成。由于患者年龄较大且存在放射学改变,怀疑为转移性癌。然而,未发现原发灶。尸检显示髋关节区域存在骨肉瘤,伴有肿瘤软骨和肿瘤骨交替形成。还存在“内分泌骨肉瘤”的未分化部分,类似癌。尽管骨骼广泛受累且有肺转移,且患者年龄较大,但未发现骨Paget病作为可能的癌前疾病的证据。