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HLA单倍型与接受转移因子治疗的儿童急性淋巴细胞白血病的长期存活

HLA haplotypes and long survival in childhood acute lymphoblastic leukaemia treated with transfer factor.

作者信息

De Bruyère M, Cornu G, Heremans-Bracke T, Malchaire J, Sokal G

出版信息

Br J Haematol. 1980 Feb;44(2):243-51. doi: 10.1111/j.1365-2141.1980.tb01206.x.

DOI:10.1111/j.1365-2141.1980.tb01206.x
PMID:6929700
Abstract

Association between HLA haplotypes and long survival was investigated in 116 children with acute lymphoblastic leukaemia. It was found that patients with A2 B12 and/or A2 B40 haplotypes survived longer than patients wtihout these two haplotypes. Since all children were treated with transfer factor obtained from their relatives, it is suggested that children possessing A2 B12 or A2 B40 haplotypes may respond better to this type of immunotherapy.

摘要

在116名急性淋巴细胞白血病儿童中研究了HLA单倍型与长期存活之间的关联。发现具有A2 B12和/或A2 B40单倍型的患者比没有这两种单倍型的患者存活时间更长。由于所有儿童均接受了从其亲属获得的转移因子治疗，因此提示具有A2 B12或A2 B40单倍型的儿童可能对这种免疫疗法反应更好。

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Chronic myelocytic leukaemia: HLA association and decreased erythrocyte C3b receptor expression.慢性粒细胞白血病：HLA关联与红细胞C3b受体表达降低
Clin Exp Immunol. 1985 Feb;59(2):300-4.