Kantorova V I
Ontogenez. 1978;9(4):333-44.
In the process of regeneration of the skull vault bones in adult rabbits which proceeds spontaneously after trepanation, the destroyed and changing bone of the defect margins is an inductor of osteogenesis. Coming into the contact with the reacting material in the region of defect and in dura mater, it directs its differention along the path of osteogenesis. In the experiments where the inductor and reacting material were separated by the millipore (0.45 mcm) filter the pores of which did not prevent the penetration of macromolecules and cell processes, the bone regeneration in the region of defect slowed down, as compared with the control. The bone formation de novo was observed in these experiments at first in the places of contact of the millipore filter covering the destroyed bone margins with the reacting material, i. e. in the regions of dura mater adjacent to the filter and in the newly formed connective tissue covering the external surface of the filter. The separation of the defect margins from the reacting material by wax inhibited the bone regeneration. The region of defect was filled by connective tissue scar.
在成年兔颅骨钻孔后自发进行的颅骨再生过程中，缺损边缘被破坏且不断变化的骨组织是骨生成的诱导物。在缺损区域和硬脑膜中，它与反应物质接触，引导其沿骨生成路径分化。在实验中，诱导物和反应物质被微孔（0.45微米）滤膜隔开，该滤膜的孔隙不妨碍大分子和细胞突起的穿透，但与对照组相比，缺损区域的骨再生减缓。在这些实验中，起初在覆盖破坏骨边缘的微孔滤膜与反应物质接触的部位，即与滤膜相邻的硬脑膜区域以及覆盖滤膜外表面的新形成结缔组织中，观察到了新骨形成。用蜡将缺损边缘与反应物质隔开会抑制骨再生。缺损区域被结缔组织瘢痕填充。
