Ooi T C, Evans M C, Spiro T P, Ibbertson H K
N Z Med J. 1980 Feb 27;91(654):134-6.
A patient with Paget's disease of bone and primary hyperparathyroidism is described. It has been suggested that a metabolite from pagetic tissue might stimulate parathyroid cell function. To test this, serum parathyroid hormone (iPTH) levels were measured by radio immunometric assay in 106 patients with Paget's disease of bone and 139 control subjects. There was no significant difference between the mean levels of the two groups. Of five sera with elevated PTH levels QUOSO extraction revealed an interfering substance in 3/5 from control patients tested and extractable iPTH in 2/2 from Paget's patients. One of the latter had renal failure. The results suggest that increased parathyroid function is unlikely to be a primary event in the genesis of Paget's disease of bone.
本文描述了一名患有骨佩吉特病和原发性甲状旁腺功能亢进症的患者。有人提出，来自佩吉特病组织的一种代谢产物可能会刺激甲状旁腺细胞功能。为了验证这一点，采用放射免疫分析法对106例骨佩吉特病患者和139名对照者的血清甲状旁腺激素（iPTH）水平进行了检测。两组的平均水平之间没有显著差异。在5例PTH水平升高的血清中，QUOSO萃取法显示，在检测的对照患者中有3/5存在干扰物质，而在佩吉特病患者中有2/2可萃取出iPTH。后者中有1例患有肾衰竭。结果表明，甲状旁腺功能增强不太可能是骨佩吉特病发病机制中的原发性事件。
