Saleem A, Johnston R L
Ann Clin Lab Sci. 1980 Mar-Apr;10(2):100-4.
Over 100 instances of acute leukemia have been reported in the course of Hodgkin's disease. The type of leukemia almost always is nonlymphoblastic. Only five well documented cases of acute lymphoblastic leukemia (ALL) have been found by us in the world literature. One case who developed ALL six years after intensive radiotherapy for Hodgkin's disease is herewith reported. The patient responded to treatment with Prednisone, Vincristine and intrathecal methotrexate and maintained a complete remission on 6-mercaptopurine for nine months. When last seen, the bone marrow revealed a mild increase in blasts indicative of an early relapse.
在霍奇金病病程中已报告了100多例急性白血病。白血病类型几乎总是非淋巴细胞性的。我们在世界文献中仅发现5例记录完善的急性淋巴细胞白血病（ALL）。本文报告1例在接受霍奇金病强化放疗6年后发生ALL的病例。该患者对泼尼松、长春新碱及鞘内注射甲氨蝶呤治疗有反应，并且在使用6-巯基嘌呤治疗下维持完全缓解9个月。最后一次就诊时，骨髓显示原始细胞轻度增多，提示早期复发。
