Breakefield X O, Giller E L, Nurnberger J I, Castiglione C M, Buchsbaum M S, Gershon E S
Psychiatry Res. 1980 Jul;2(3):307-14. doi: 10.1016/0165-1781(80)90022-0.
No differences in levels of type A monoamine oxidase (MAO) were observed in cultured human skin fibroblasts from nine patients with bipolar depressive illness as compared to 18 age-, sex-, and race-matched controls. All cells were biopsied and cultured under parallel conditions. Fibroblasts from monozygotic twins (three sets) had levels of MAO activity that were highly concordant, indicating that levels measured in fibroblasts are genetically determined. Together these findings suggest that an inherited predisposition to bipolar depressive illness does not involve inherited variations in levels of type A MAO activity. Using a larger control population, a positive correlation was observed between age of donor and level of MAO activity. This finding demonstrates the need for age-matched control and patient groups when comparing levels of type A MAO in fibroblasts.
与18名年龄、性别和种族匹配的对照相比，在9名双相抑郁障碍患者的培养人皮肤成纤维细胞中未观察到A型单胺氧化酶（MAO）水平的差异。所有细胞均在平行条件下进行活检和培养。来自同卵双胞胎（三组）的成纤维细胞具有高度一致的MAO活性水平，这表明在成纤维细胞中测得的水平是由基因决定的。这些发现共同表明，双相抑郁障碍的遗传易感性并不涉及A型MAO活性水平的遗传变异。使用更大的对照人群时，观察到供体年龄与MAO活性水平之间存在正相关。这一发现表明，在比较成纤维细胞中A型MAO水平时，需要年龄匹配的对照和患者组。
