Spiegel R J, Echelberger C K, Poplack D G
Med Pediatr Oncol. 1980;8(2):123-5. doi: 10.1002/mpo.2950080204.
L-asparaginase, a highly effective anti-leukemic enzyme preparation is now frequently being administered intramuscularly in order to decrease the incidence of severe sensitivity reactions. Although the occurrence of immediate hypersensitivity reactions and anaphylaxis has been diminished through this technique, we report three patients who developed delayed allergic reactions occurring hours after drug administration. This suggests that patients receiving L-asparaginase intramuscularly merit prolonged observation periods beyond the usual one half to one hour.
L-天冬酰胺酶是一种高效的抗白血病酶制剂，目前常通过肌肉注射给药，以降低严重过敏反应的发生率。尽管通过这种技术，速发型过敏反应和过敏症的发生率有所降低，但我们报告了3例患者在药物注射数小时后出现迟发型过敏反应。这表明，接受肌肉注射L-天冬酰胺酶的患者值得延长观察期，超出通常的半小时至1小时。
