Chan K W, Miller D R, Tan C T
Med Pediatr Oncol. 1980;8(2):143-9. doi: 10.1002/mpo.2950080207.
A child diagnosed with Stage IVB Hodgkin disease at nine and one-half years of age subsequently developed osteosarcoma and acute myelogenous leukemia ten years after her initial diagnosis. She received multiple courses of radiotherapy and several single chemotherapeutic agents for her Hodgkin disease. Theraphy-induced multiple malignancies and intrinsic predisposition to carcinogenesis in this case is discussed.
一名9岁半时被诊断为IVB期霍奇金病的儿童，在初次诊断十年后，继而患上了骨肉瘤和急性髓细胞白血病。她因霍奇金病接受了多个疗程的放疗和几种单一化疗药物治疗。本文讨论了该病例中治疗引起的多种恶性肿瘤以及致癌的内在易感性。
