一名急性红白血病患者B、I、i及Lewisb抗原的改变

Modifications of B, I, i, and Lewisb antigens in a patient with DiGuglielmo's erythroleukemia.

作者信息

Kolins J, Allgood J W, Burghardt D C, Klein H G, McGinniss M H

出版信息

Transfusion. 1980 Sep-Oct;20(5):574-7. doi: 10.1046/j.1537-2995.1980.20581034514.x.

DOI:10.1046/j.1537-2995.1980.20581034514.x

Abstract

Loss of red blood cell antigens has been documented in patients with acute myelocytic leukemia and includes loss of A, B, and H antigens in the ABO system as well as antigens of the Rh, MNSsU, Lewis and Ii systems. The following case represents partial loss of the B, I and Lewisb antigens in a patient with erythroleukemia. Also, the loss of the I antigen was associated with a concomitant increase in i antigen, a known but rare finding. These changes within the ABO, Ii, and Lewis systems do not appear to be coincidental, as these blood group systems share a common biochemical backbone.

摘要

急性髓细胞白血病患者中已记录到红细胞抗原缺失，包括ABO系统中A、B和H抗原的缺失以及Rh、MNSsU、Lewis和Ii系统的抗原缺失。以下病例代表了一名红白血病患者中B、I和Lewisb抗原的部分缺失。此外，I抗原的缺失与i抗原的同时增加有关，这是一个已知但罕见的发现。ABO、Ii和Lewis系统内的这些变化似乎并非巧合，因为这些血型系统共享一个共同的生化主干。