Jonsson G, Hallman H
Acta Physiol Scand Suppl. 1980;479:25-6.
The effects of neonatal nicotine and/or 6-hydroxydopamine (6-OH-DA) treatment on the postnatal development of central noradrenaline (NA) neurons have been investigated using neurochemical and histochemical techniques. Nicotine was found to produce an increase of 3H-NA uptake and endogenous NA in the cerebral cortex and pons-medulla, which was most pronounced at the age of one week. These parameters were normalized in the adult stage. Neonatal nicotine treatment was also found to partially counteract the 6-OH-DA induced alteraton of the development of the locus coeruleus NA system. The NA denervation produced by 6-OH-DA in the cerebral cortex and the spinal cord was thus counteracted by nicotine treatment. The results suggest that neonatal nicotine administration has a growth stimulatory effect on the early postnatal development of central NA neurons.
已使用神经化学和组织化学技术研究了新生期尼古丁和/或6-羟基多巴胺（6-OH-DA）处理对中枢去甲肾上腺素（NA）神经元出生后发育的影响。发现尼古丁可使大脑皮层和脑桥-延髓中3H-NA摄取和内源性NA增加，这在1周龄时最为明显。这些参数在成年期恢复正常。还发现新生期尼古丁处理可部分抵消6-OH-DA诱导的蓝斑NA系统发育改变。因此，尼古丁处理可抵消6-OH-DA在大脑皮层和脊髓中产生的NA去神经支配。结果表明，新生期给予尼古丁对中枢NA神经元出生后的早期发育具有生长刺激作用。
