Hockings B E, Cope G D, Clarke G M, Taylor R R
Aust N Z J Med. 1980 Aug;10(4):420-5. doi: 10.1111/j.1445-5994.1980.tb04093.x.
The acute haemodynamic effects of prazosin 5 mg were investigated in 11 patients with severe chronic congestive cardiac failure. Six patients had their antifailure therapy discontinued while five continued on their usual medication. Two patients were exercised before and after prozosin. Following the drug, pulmonary capilary wedge pressure diminished 7 +/- 2(SE) mmHg (P < 0.005) and cardiac index increased 17 +/- 6% (P < 0.02). Mean arterial pressure fell in all subjects (- 9 +/- 2 mmHg; P < 0.001) and systemic vascular resistance was reduced in all but one (- 19 +/- 5%; P < 0.005). There was no significant change in heart rate. Four of the five subjects whose regular medications were continued were evaluated by clinical examination, chest X-ray, echocardiogram and treadmill stress test, before and after four weeks of prazosin therapy, one subject having died in this time. Two improved, one deteriorated and one remained unchanged. Thus, chronic prazosin therapy benefited individual patients but did not consistently provide long term improvement.
对11例严重慢性充血性心力衰竭患者研究了5毫克哌唑嗪的急性血流动力学效应。6例患者停用抗心力衰竭治疗，而5例继续使用常规药物。2例患者在服用哌唑嗪前后进行了运动试验。用药后，肺毛细血管楔压降低7±2（标准误）毫米汞柱（P<0.005），心脏指数增加17±6%（P<0.02）。所有受试者的平均动脉压均下降（-9±2毫米汞柱；P<0.001），除1例之外所有受试者的全身血管阻力均降低（-19±5%；P<0.005）。心率无显著变化。在继续服用常规药物的5例受试者中，4例在哌唑嗪治疗4周前后接受了临床检查、胸部X光、超声心动图和跑步机应激试验评估，在此期间有1例受试者死亡。2例病情改善，1例恶化，1例无变化。因此，慢性哌唑嗪治疗使个别患者受益，但并不能始终提供长期改善。
