Coiffier B, Bryon P A, Fiere D, Felman P, Gentillomme O, Vu Van H, Viala J J, Germain D
Biomedicine. 1980 Jul-Aug;33(4):96-8.
The study of bone marrow granulocytic precursors (GM CFU-C) has been made in patients with a chronic granulocytic leukemia (CGL), at diagnosis and during the evolution. In vitro growth was increased with a normal clusters/colonies ratio in 17 patients, 2 have presented a metamorphosis. In vitro growth was abnormal in 30 patients, 22 have presented a metamorphosis with a median of 9 months after the in vitro study. The in vitro growth of GM CFU-C in CGL patients could detect the metamorphosis.
对慢性粒细胞白血病（CGL）患者在诊断时及病情发展过程中的骨髓粒细胞前体（GM CFU-C）进行了研究。17例患者的体外生长增加，集簇/集落比值正常，2例出现了细胞变态。30例患者的体外生长异常，22例出现了细胞变态，体外研究后中位时间为9个月。CGL患者GM CFU-C的体外生长可检测到细胞变态。
