慢性粒细胞白血病骨髓细胞及PHA刺激的外周血培养物中出现新的复杂Ph'易位t(10;14;22) 。
New complex Ph' translocation t (10; 14; 22) in bone marrow cells and in PHA-stimulated peripheral blood cultures in chronic myelocytic leukaemia.
作者信息
Shabtai F, Gafter U, Weiss S, Djaldetti M, Halbrecht I
出版信息
J Cancer Res Clin Oncol. 1980;96(3):287-94. doi: 10.1007/BF00408101.
Abstract
A patient with chronic myelocytic leukaemia (CML) and a new complex Philadelphia chromosome (Ph') translocation, t (10; 14; 22), is described. This three way Ph' translocation not involving chromosome 9 was present in the majority of the bone marrow cells, as well as in a great proportion of metaphases from phytohaemagglutinin (PHA) stimulated peripheral blood cultures. The possibility that the Ph' translocation was present also in lymphocytes is discussed and at this regard the involvement of chromosome 14 is of interest considering the documented non random involvement of chromosome 14 in lymphoid malignancies.
摘要
本文描述了一名患有慢性粒细胞白血病（CML）且伴有新的复杂费城染色体（Ph'）易位，即t（10；14；22）的患者。这种不涉及9号染色体的三向Ph'易位存在于大多数骨髓细胞中，以及来自植物血凝素（PHA）刺激的外周血培养物的很大一部分中期细胞中。文中讨论了Ph'易位也存在于淋巴细胞中的可能性，在这方面，考虑到文献记载14号染色体在淋巴系统恶性肿瘤中的非随机参与，14号染色体的受累情况值得关注。
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