Keene H J, Mellberg J R, Pederson E D
J Dent Res. 1980 Nov;59(11):1941-5. doi: 10.1177/00220345800590110301.
An in vivo enamel biopsy technique was used to determine relationships between dental caries experience and surface enamel fluoride levels in a group of young men from three fluoridated cities on the east coat of the U.S. A significant inverse relationship between enamel thickness and fluoride concentration was observed, and a weak but statistically significant inverse relationship between caries scores and enamel fluoride concentration was noted. The effect was most pronounced in biopsies which did not exceed 5.9 micron in depth.
采用一种体内牙釉质活检技术，来确定美国东海岸三个实行氟化水防龋的城市中一组年轻男性的龋齿患病情况与牙釉质表面氟含量之间的关系。观察到牙釉质厚度与氟浓度之间存在显著的负相关关系，并且龋齿评分与牙釉质氟浓度之间存在微弱但具有统计学意义的负相关关系。这种效应在深度不超过5.9微米的活检样本中最为明显。
