Fahn S, Mayeux R
J Neural Transm Suppl. 1980(16):179-85. doi: 10.1007/978-3-7091-8582-7_20.
A unique case reported of a patient with right-sided Parkinson's disease and left-sided tardive dyskinesia. This situation occurred because the patient's parkinsonian tremor was treated with antipsychotic drugs. After several months she developed tardive dyskinesia on the left side of the body. Successful treatment was achieved nine years later, using dopamine-depleting drugs (combination reserpine and alpha-methylparatyrosine) to suppress the tardive dyskinesia and trihexyphenidyl to reduce the parkinsonism. Control of the symptoms was complicated with parkinsonism symptoms later increased on the right and developed on the left, due to the dopamine-depleting drugs. A small amount of carbidopa/levodopa restored the proper balance of symptoms, effectively reducing the parkinsonism while not aggravating the tardive dyskinesia. This unique case provides insight into the pathogeneis of Parkinson's disease, the pathogenesis of tardive dyskinesia, their successful therapeutic approaches, and possibly the effect of drugs in blocking the progression of Parkinson's disease.
报道了一例独特病例，患者右侧患有帕金森病，左侧患有迟发性运动障碍。出现这种情况是因为该患者的帕金森震颤用抗精神病药物进行了治疗。几个月后，她身体左侧出现了迟发性运动障碍。九年后，通过使用耗竭多巴胺的药物（利血平与α-甲基对酪氨酸联合使用）来抑制迟发性运动障碍，并使用苯海索来减轻帕金森症状，成功实现了治疗。症状的控制较为复杂，由于使用了耗竭多巴胺的药物，右侧帕金森症状后来加重，左侧也出现了帕金森症状。少量的卡比多巴/左旋多巴恢复了症状的适当平衡，有效减轻了帕金森症状，同时又不加重迟发性运动障碍。这个独特的病例为帕金森病的发病机制、迟发性运动障碍的发病机制、它们的成功治疗方法以及药物在阻断帕金森病进展方面的可能作用提供了见解。
