T-lymphocyte differentiation antigens shared by humans and rhesus monkeys.

Anti-human T-lymphocyte serum (anti-HTLA) was used to investigate the relationship between differentiation antigens of human (HTLA) and Macaca lymphocytes. The percentage of lymphocytes sensitive to anti-HTLA is the same in both species, with thymocytes having a higher concentration of HTLA than more mature T-lymphocytes. Macaca bone marrow cells acquire phenotypic properties of T-lymphocytes in vitro in the presence of calf thymic factors. Our data suggest that phylogenetic distinctions between various T-lymphocyte differentiation antigens may be utilized to provide antisera of narrow specificity.