针对小鼠囊胚形成过程中滋养外胚层特异性标志物的单克隆抗体。
Monoclonal antibodies against trophectoderm-specific markers during mouse blastocyst formation.
作者信息
Brûlet P, Babinet C, Kemler R, Jacob F
出版信息
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4113-7. doi: 10.1073/pnas.77.7.4113.
Abstract
Two-dimensional gel electrophoresis has allowed the detection of proteins characteristic of inner cell mass and trophectoderm in mouse blastocyst. Certain of the proteins characterizing trophectoderm copurify with intermediate filaments from trophectoderm and a trophoblastoma cell line. A monoclonal antibody prepared against proteins of these intermediate filaments labels a filament network in trophectoderm but not in inner cell mass cells.
摘要
二维凝胶电泳已能够检测小鼠囊胚中内细胞团和滋养外胚层的特征性蛋白质。某些表征滋养外胚层的蛋白质与来自滋养外胚层和一种滋养层细胞瘤细胞系的中间丝共同纯化。针对这些中间丝的蛋白质制备的单克隆抗体标记滋养外胚层中的丝状网络，但不标记内细胞团细胞中的丝状网络。
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