通过肾脏酶排泄研究评估药物的肾毒性。

Nephrotoxicity of drugs, evaluated by renal enzyme excretion studies.

作者信息

Raab W

出版信息

Arch Toxicol Suppl. 1980;4:194-200. doi: 10.1007/978-3-642-67729-8_42.

Abstract

Via various pathways, urinary enzymatic activities are changed by drugs. Nephrotoxic effects may be determined by such investigations. Numerous experimental series have formed the basis for the clinical application of this method. The pertinent data collected with analgesics and antibiotics, alone or in combinations, are discussed in this paper. The data from the literature were compared with personal investigations, in animals as well as in man. It is concluded that - under certain precautions - the nephrotoxicity of drugs can be evaluated by renal enzyme excretion studies.

摘要

通过各种途径，药物会改变尿液中的酶活性。此类研究可确定肾毒性作用。众多实验系列构成了该方法临床应用的基础。本文讨论了单独或联合使用镇痛药和抗生素收集到的相关数据。将文献数据与在动物和人体上的个人研究数据进行了比较。得出的结论是——在采取某些预防措施的情况下——可通过肾脏酶排泄研究评估药物的肾毒性。