Tancheva L, Stoytchev T
Arch Toxicol Suppl. 1980;4:328-30. doi: 10.1007/978-3-642-67729-8_68.
In experiments on albino rats of both sexes it has been established that hydrocortisone applied in a single dose of 50 mg/kg i.p. inhibits hexobarbital oxidase and ethylmorphine-N-demethylase and applied repeatedly in a dose of 10 mg/kg increases the activity of both enzymes. In castrated male rats the enzyme-inhibiting action of the single dose of hydrocortisone is much reduced, while its enzyme-inducing action on repeated application remains the same (the two effects are evaluated by the hexobarbital sleeping time).
在对雌雄白化大鼠进行的实验中发现，腹腔注射50mg/kg单剂量的氢化可的松会抑制己巴比妥氧化酶和N-脱甲基乙基吗啡酶，而以10mg/kg剂量反复给药则会增强这两种酶的活性。在去势雄鼠中，单剂量氢化可的松的酶抑制作用大大减弱，而反复给药时其酶诱导作用保持不变（两种作用均通过己巴比妥睡眠时间来评估）。
