通过与DNA、金属离子形成复合物以及用α-生育酚预处理来改变紫霉素BI（VBI）的毒性。

Modification of toxicity of violamycin BI (VBI) by complex formation with DNA, metal ions, and by pretreatment with alpha-tocopherol.

作者信息

Härtl A, Kirchner E, Fleck W F, Unger E, Hoffmann H

出版信息

Arch Toxicol Suppl. 1980;4:396-8. doi: 10.1007/978-3-642-67729-8_88.

Abstract

In connection with studies on lowering the toxicity of violamycin BI (VBI) the intravenous (i.v.) LD50 values were determined in mice for VBI, VBI complexed with DNA, Fe3+ or Pt2+, and after pretreatment with alpha-tocopherol. The results indicate that the toxicity of VBI is reduced by complex formation with DNA or ferric ions including a partial decrease of the antimicrobial and antiviral activity.

摘要

在关于降低紫霉素BI（VBI）毒性的研究中，测定了小鼠静脉注射（i.v.）VBI、与DNA、Fe3+或Pt2+络合的VBI以及用α-生育酚预处理后的LD50值。结果表明，与DNA或铁离子形成络合物可降低VBI的毒性，包括抗菌和抗病毒活性部分降低。