β-氯代乙烯基酮和醛类对啮齿动物的急性和皮肤毒性

Acute and cutaneous toxicity of beta-chlorovinyl ketones and aldehydes in rodents.

作者信息

Riemer F, Grüttner S, Hegewald G, Stolp A, Fischer G W, Gudian R, Spiegelberger E, Fieber C, Grisk A

出版信息

Arch Toxicol Suppl. 1980;4:421-4. doi: 10.1007/978-3-642-67729-8_97.

Abstract

The acute toxicity (LD50, intraperitoneal in the mouse) of beta-chlorovinyl ketones and aldehydes used as intermediates for organic syntheses was determined and their action on the skin of rodents investigated. Ketones of the type Cl-CH-CH-COR prove to be relatively toxic and display a markedly necrotic action after percutaneous absorption. In comparison with this the isomeric aldehydes Cl-CR-CH-CHO have a lower acute and less markedly cutaneous toxicity. As therapeutic counter action after skin contamination by beta-chlorovinyl carbonyl compounds the immediate treatment with an aqueous ethanolic solution of hexamethylenetetramine is recommendable.

摘要

测定了用作有机合成中间体的β-氯代乙烯基酮和醛的急性毒性（小鼠腹腔注射的半数致死量），并研究了它们对啮齿动物皮肤的作用。Cl-CH-CH-COR型酮具有较高的毒性，经皮吸收后表现出明显的坏死作用。相比之下，异构体醛Cl-CR-CH-CHO的急性毒性较低，皮肤毒性也不那么明显。对于β-氯代乙烯基羰基化合物污染皮肤后的治疗，建议立即用六亚甲基四胺的乙醇水溶液进行处理。