Tesseromatis C, Galanopoulou P, Varonos D
Arch Toxicol Suppl. 1980;4:492-8. doi: 10.1007/978-3-642-67729-8_117.
25 albino rats of Wistar strain were used for the study. They were divided into three groups. Animals of the first group (n = 10) were treated with Diphenylhydantoin in a daily dose of 70 mg/kg for three months. Animals of the second group (n = 10) were treated with Diazepam in a daily dose of 10 mg/kg for 3 months. Animals of the third group (n = 5) were treated with 5% acacia oil for the same period of time. Food and water consumption together with motor activity were measured. As indices of enzyme induction, D-Glucaric acid and liver weight were determined. Also the following bone indices were determined: femur Ca/femur weight, femur Ca/body weight, humerus Ca/humerus weight, humerus Ca/body weight, femur specific weight, humerus specific weight. Statistically significant alterations of bone mass were found.
选用25只Wistar品系的白化大鼠进行该研究。它们被分为三组。第一组动物（n = 10）每天以70毫克/千克的剂量给予苯妥英，持续三个月。第二组动物（n = 10）每天以10毫克/千克的剂量给予地西泮，持续3个月。第三组动物（n = 5）在相同时间段内给予5%阿拉伯胶油。测量食物和水的消耗量以及运动活性。作为酶诱导指标，测定D - 葡糖醛酸和肝脏重量。还测定了以下骨骼指标：股骨钙/股骨重量、股骨钙/体重、肱骨钙/肱骨重量、肱骨钙/体重、股骨比重、肱骨比重。发现骨量有统计学意义的改变。
