Ogilvie-Harris D J, Fornasier V L
J Bone Joint Surg Am. 1980 Dec;62(8):1274-83.
Circumscribed heterotopic new-bone formation without a history of trauma is termed pseudomalignant myositis ossificans due to the diagnostic confusion of this benign lesion with malignant lesions. In 20 per cent of the published cases in which there were diagnostic problems, the patient underwent a radical procedure. Roentgenographically, pseudomalignant myositis ossificans is a circumscribed, radiopaque lesion with a central lucent zone that is separated from the underlying cortex by a radiolucent line. Histologically, a characteristic zoning pattern of peripheral maturation is present, the central proliferating zone usually causing the diagnostic problems. The ultrastructure of the lesion shows a regular mineralization front but an abnormal collagen periodicity of 300 angstroms. Excision is indicated for diagnosis and for relief of mechanical block or pain.
无创伤史的局限性异位新骨形成被称为假恶性骨化性肌炎，这是因为这种良性病变与恶性病变在诊断上容易混淆。在已发表的病例中，有20%存在诊断问题，患者接受了根治性手术。在X线片上，假恶性骨化性肌炎是一种局限性的不透X线病变，中央有透亮区，与下方皮质之间有一条透X线的线分隔。组织学上，存在外周成熟的特征性分层模式，中央增殖区通常会导致诊断问题。病变的超微结构显示有规则的矿化前沿，但胶原周期异常，为300埃。切除适用于诊断以及缓解机械性梗阻或疼痛。
