Renoir J M, Mercier-Bodard C, Baulieu E E
J Reprod Fertil Suppl. 1980;Suppl 28:113-9.
Sex steroid-binding plasma protein binds dihydrotestosterone, testosterone, and oestradiol with high affinity (Kd,eq. approximately 0.5, 1 and 2 nM, respectively), in man (h-SBP) and in monkeys. Steroid-binding specificity is identical in all primates. However oestrone does not displace dihydrotestosterone binding in man or chimpanzee. Gel filtration experiments and immunoelectrophoretic analysis with a mono-specific antiserum raised in the rabbit against h-SBP indicate cross-reactivity with primate SBPs (from complete in chimpanzee and gorilla to weak in prosimians), but no cross-reaction with other mammalian androgen-binding plasma proteins.
性类固醇结合血浆蛋白在人类（h-SBP）和猴子体内以高亲和力（解离常数Kd，分别约为0.5、1和2 nM）结合二氢睾酮、睾酮和雌二醇。在所有灵长类动物中，类固醇结合特异性是相同的。然而，雌酮在人类或黑猩猩中不会取代二氢睾酮的结合。凝胶过滤实验以及用针对h-SBP在兔体内产生的单特异性抗血清进行的免疫电泳分析表明，与灵长类动物的SBP存在交叉反应（在黑猩猩和大猩猩中完全交叉反应，在原猴亚目中较弱），但与其他哺乳动物雄激素结合血浆蛋白无交叉反应。
