Ross-Stanton J, Schlessinger S, Meltzer H Y
Psychiatry Res. 1980 Sep;3(1):53-67. doi: 10.1016/0165-1781(80)90047-5.
A broad range of skeletal muscle fiber abnormalities has been reported previously in muscle biopsy specimens from psychotic patients. In our experience, individual patients manifest only a few types of lesions; but we now have studied a paranoid schizophrenic patient whose skeletal muscle fibers show virtually the entire range of morphologic abnormalities. In addition to the morphologic abnormalities of skeletal muscle fibers, we also noted increased branching of subterminal motor nerves with enlarged endplates and chronic elevations of serum creatine phosphokinase activity. Despite this, the patient had minimal clinical evidence of neuromuscular dysfunction. The variety of types of neuromuscular dysfunctions found in this patient suggests their etiology may be related.
先前已有报道称，在精神病患者的肌肉活检标本中存在广泛的骨骼肌纤维异常情况。据我们的经验，个别患者仅表现出少数几种类型的病变；但我们现在研究了一名偏执型精神分裂症患者，其骨骼肌纤维几乎呈现出了所有形态学异常。除了骨骼肌纤维的形态学异常外，我们还注意到终末运动神经分支增多，终板增大，血清肌酸磷酸激酶活性长期升高。尽管如此，该患者几乎没有神经肌肉功能障碍的临床证据。在该患者中发现的多种神经肌肉功能障碍类型表明，它们的病因可能有关联。
