Sandrin M S, Henning M M, Vaughan H A, McKenzie I F, Parish C R
J Natl Cancer Inst. 1981 Feb;66(2):279-83.
Antigen stimulation in mice such as occurs with the rejection of an allogeneic tumor graft caused a substantial rise in serum glycolipid Ia levels. However, mice bearing a measurable syngeneic tumor had no detectable Ia antigens in their sera; this observation was made in several different strains of inbred mice with 5 different tumors. In each instance the serum Ia level fell as the tumor grew progressively, reached zero at about the time the tumor was visible, and remained at this zero level until the mouse died. Similar results were found in humans: Tumor-bearing patients had markedly suppressed serum Ia levels. The mechanism of the fall in serum Ia glycolipid levels is not known, but the measurement of the serum Ia glycolipid content appears to reflect the level of activation of the immune system, and the suppression of serum glycolipid Ia levels found in tumor-bearing mice and patients may have important clinical implications.
小鼠体内的抗原刺激，如在同种异体肿瘤移植排斥反应中所发生的那样，会导致血清糖脂Ia水平大幅上升。然而，携带可测量的同基因肿瘤的小鼠血清中未检测到Ia抗原；这一观察结果在几种不同品系的近交小鼠以及5种不同肿瘤中均得到证实。在每种情况下，血清Ia水平随着肿瘤的逐渐生长而下降，在肿瘤可见时降至零，并在小鼠死亡前一直维持在这一零水平。在人类中也发现了类似的结果：患肿瘤的患者血清Ia水平明显受到抑制。血清糖脂Ia水平下降的机制尚不清楚，但血清糖脂Ia含量的测量似乎反映了免疫系统的激活水平，在患肿瘤的小鼠和患者中发现的血清糖脂Ia水平的抑制可能具有重要的临床意义。
