Two cases of villous adenoma of the duodenum are presented. One patient had two lesions in the first part of the duodenum, this being only the second report of multiple villous adenomas of the duodenum. One patient was totally asymptomatic and his villous adenoma was diagnosed radiologically during investigation of anaemia, while the second patient had his two villous adenomas discovered incidentally during surgery for a bleeding leiomyosarcoma of the stomach. The two duodenal adenomas in the second patient had been missed on the barium study.