Garrafa V, Okamoto T, dos Santos Pinto R
Oral Surg Oral Med Oral Pathol. 1980 Nov;50(5):398-403. doi: 10.1016/s0030-4220(80)80005-3.
The effect of cyclophosphamide on transplanted continuously growing teeth was studied histologically. Two groups of 36 rats each were used in this study. Rats of Group I underwent dental transplants and postoperative sutures. Those of Group II underwent the same procedures and received daily doses of the cytostatic agent until the day of sacrifice. An analysis was made of cyclophosphamide action on epithelium of the gingival mucosa, periodontal ligament, alveolar osseous tissue, connective tissue situated between the bone and enamel, cementum, dentin, and dental pulp. Cyclophosphamide prevents the appearance of atypical mineralized masses and dental germs.
对环磷酰胺对移植的持续生长牙齿的影响进行了组织学研究。本研究使用了两组大鼠，每组36只。第一组大鼠接受牙齿移植和术后缝合。第二组大鼠接受相同的手术，并每天给予细胞抑制剂，直至处死之日。分析了环磷酰胺对牙龈黏膜上皮、牙周韧带、牙槽骨组织、骨与牙釉质之间的结缔组织、牙骨质、牙本质和牙髓的作用。环磷酰胺可防止非典型矿化团块和牙胚的出现。
