Lecointre F, Marandas P, Micheau C, Richard J, Rolland J, Cachin Y
Rev Stomatol Chir Maxillofac. 1980;81(6):376-84.
Fifty patients with primary epidermoid carcinomas of the nasal sinuses were treated by intra-arterial chemotherapy, alone (2 fatal iatrogenic accidents occurred) or in association with surgery and/or radiotherapy (48 cases). Adverse reactions due to chemotherapy were noted in 11 patients (22%), and two of these were fatal (4%). In eleven patients (22%) the initial curative chemotherapy was unsuccessful and all died after a mean survival period of 12 months. Local recurrence was observed in 7 patients (14%), the mean survival period being 11,5 months, and in 6 patients (12%) with local glandular involvement the mean period was 15 months. Identical survival rates of 57% after 3 years (8/14) and 50% after 5 years (6/12) were observed in 14 cases with endosinusal forms and 14 patients in whom the infrastructures were treated. In 22 patients there was exteriorization of the lesion, and the survival rate was 31% after 3 years (7/22) and 15% after 5 years (3/19). All 7 patients with pterygomaxillary lesions died within 3 years. Overall results in the 50 patients treated show that: -- 23/50 (46%) survived for 3 years -- 15/43 (35%) for 5 years -- 5/19 (26%) for 10 years.
50例鼻窦原发性表皮样癌患者接受了动脉内化疗，单独化疗（发生2例致命性医源性事故）或联合手术和/或放疗（48例）。11例患者（22%）出现化疗不良反应，其中2例死亡（4%）。11例患者（22%）初始的根治性化疗未成功，均在平均生存期12个月后死亡。7例患者（14%）出现局部复发，平均生存期为11.5个月，6例有局部腺体受累的患者平均生存期为15个月。14例鼻窦内型患者和14例接受基础结构治疗的患者3年后生存率均为57%（8/14），5年后生存率均为50%（6/12）。22例患者病变有外部表现，3年后生存率为31%（7/22），5年后生存率为15%（3/19）。所有7例翼上颌病变患者均在3年内死亡。接受治疗的50例患者的总体结果显示：——23/50（46%）存活3年——15/43（35%）存活5年——5/19（26%）存活10年。
