与卡马西平相关的粒细胞缺乏症，以及恢复期间与抗淋巴细胞白血病抗血清的阳性反应。
Agranulocytosis associated with carbamazepine, and a positive reaction with anti-lymphoid leukaemia antiserum during recovery.
作者信息
Owens C W, Parker N E, Nunn P P, Davies J
出版信息
Postgrad Med J. 1980 Sep;56(659):665-8. doi: 10.1136/pgmj.56.659.665.
Abstract
Carbamazepine is a valuable drug in the treatment of trigeminal neuralgia and temporal lobe epilepsy. Rarely agranulocytosis has been described associated with its use but in this further non-fatal case a new finding of a positive reaction with anti-lymphoid leukaemia anti-serum was seen during the recovery phase. A brief review of 18 cases in the literature is provided and it is noted that 94% of reported cases are over the age of 45 years. The significance of the haematological finding is discussed.
摘要
卡马西平是治疗三叉神经痛和颞叶癫痫的一种重要药物。虽然很少有关于使用卡马西平后出现粒细胞缺乏症的报道，但在这例新的非致命病例中，在恢复阶段发现了与抗淋巴细胞白血病抗血清呈阳性反应的新情况。本文简要回顾了文献中报道的18例病例，并指出94%的报告病例年龄超过45岁。文中还讨论了血液学检查结果的意义。
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