以色列寻常型天疱疮患者中的HLA - DRw4

HLA-DRw4 in pemphigus vulgaris patients in Israel.

作者信息

Brautbar C, Moscovitz M, Livshits T, Haim S, Hacham-Zadeh S, Cohen H A, Sharon R, Nelken D, Cohen T

出版信息

Tissue Antigens. 1980 Sep;16(3):238-43. doi: 10.1111/j.1399-0039.1980.tb00299.x.

DOI:10.1111/j.1399-0039.1980.tb00299.x

Abstract

Pemphigus vulgaris (PV) is relatively common in Jews. Three HLA antigens were significantly more frequent in 39 Israeli Jewish PV patients than in controls A26 - 59% vs 20%; Bw38 - 61% vs 20%; and DRw4 - 90% vs 38%. The joint occurrence of A26-Bw38-DRw4 was observed in 46% of PV patients and in 10% of controls. Similar results were recently reported for Jews in the Los Angeles area. Yet, when our patient sample was grouped into Ashkenazi and non-Ashkenazi Jews, it was evident that each of the three antigens had a higher frequency both in Ashkenazi patients and controls as compared to non-Ashkenzai. The relative risk for DRw-4 in Ashkenzim was 33.8 as compared to 14.4 in the total sample of Israeli PV patients. The phenotype A26-Bw38-DRw4 was present in 57% of Ashkenazi patients and in 13% of controls. Ashkenazi Jews have the highest prevalence of PV, and HLA associations were strongest with Ashkenazi PV patients. These associations were with three antigens, all of high frequency in that group.

摘要

寻常型天疱疮（PV）在犹太人中相对常见。在39名以色列犹太PV患者中，三种人类白细胞抗原（HLA）的出现频率显著高于对照组：A26为59%，而对照组为20%；Bw38为61%，对照组为20%；DRw4为90%，对照组为38%。46%的PV患者出现A26 - Bw38 - DRw4的联合出现，而对照组为10%。最近洛杉矶地区的犹太人也报告了类似结果。然而，当我们将患者样本分为德系犹太人（Ashkenazi）和非德系犹太人时，很明显，与非德系犹太人相比，这三种抗原在德系犹太患者和对照组中的出现频率都更高。德系犹太人中DRw4的相对风险为33.8，而以色列PV患者总样本中的相对风险为14.4。A26 - Bw38 - DRw4表型在57%的德系犹太患者中出现，而对照组为13%。德系犹太人中PV的患病率最高，HLA关联在德系犹太PV患者中最为显著。这些关联涉及三种抗原，在该群体中出现频率都很高。