在压缩过程中实现了DNA碱基的两种长程取向模式。
Two modes of longe-range orientation of DNA bases realized upon compaction.
作者信息
Salyanov V I, Berg H
出版信息
Nucleic Acids Res. 1981 Feb 11;9(3):743-52. doi: 10.1093/nar/9.3.743.
Formation of compact particles from linear DNA-anthracycline complexes is accompanied by appearance of intense bands in the CD spectra in the region of absorption of DNA bases (UV-region) and in the region of absorption of anthracycline chromophores (visible region). The intense (positive or negative) bands in the region of anthracycline absorption demonstrate an ordered helical location of anthracycline molecules on the DNA template. This fact, in its turn, is related to formation of the DNA superstructure in PEG-containing water-salt solutions with a long-range orientation of nitrogen bases. Possible types of DNA superstructures and the relation between the local- and the long-range order of bases in the DNA superstructure are discussed.
线性DNA-蒽环类药物复合物形成紧密颗粒的过程中，在DNA碱基吸收区域（紫外区）和蒽环类发色团吸收区域（可见光区）的圆二色光谱中会出现强吸收带。蒽环类药物吸收区域的强（正或负）吸收带表明蒽环类药物分子在DNA模板上呈有序螺旋排列。这一事实反过来又与含聚乙二醇的水盐溶液中DNA超结构的形成有关，其中碱基具有长程取向。本文讨论了DNA超结构的可能类型以及DNA超结构中碱基的局部和长程有序之间的关系。
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