Sternlieb I, Fisher M, Scheinberg I H
J Rheumatol Suppl. 1981 Jan-Feb;7:149-54.
D-penicillamine therapy can produce an unusual variety of skin lesions: Some are acute sensitivity reactions; some are caused by metabolic effects of the drug; some are due to autoimmune phenomena or to unknown mechanisms. The type and incidence of side effects depend on the original disease and on penicillamine dosage and duration of treatment.