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用前列腺素(PGF2α)抑制弗氏病毒(FVP)诱导的小鼠红细胞生成:促红细胞生成素的增强和抑制作用以及用PGD2对两者的预防作用。

Inhibition of Friend virus (FVP)-induced murine erythropoiesis with prostaglandin (PGF2 alpha): potentiation and inhibition of erythropoietin and prevention of both with PGD2.

作者信息

Lewis J P, Moores R R, Neal W A, Garver F A, Lutcher C L, Zucali J R, Mirand E A

出版信息

Exp Hematol. 1981 May;9(5):540-9.

PMID:6940758
Abstract

An erythropoietin-independent virus-induced murine erythroleukemia (FVP) is used to compare the effects of an erythropoiesis inhibitory factor (EIF) isolated from human urine with the effects of prostaglandin F2 alpha. The consequent inhibition of FVP-induced erythropoiesis suggests that EIF and PGF2 alpha have similar effects on the FVP-induced erythropoiesis in mice, and the effect of PGF2 alpha is indirect. The similarity of the actions of EIF and PGF2 alpha may indicate a potential role for prostaglandins in the physiological control of some types of erythrocytosis.

摘要

一种不依赖促红细胞生成素的病毒诱导型小鼠红白血病(FVP)被用于比较从人尿中分离出的促红细胞生成抑制因子(EIF)与前列腺素F2α的作用效果。FVP诱导的红细胞生成受到的后续抑制表明,EIF和前列腺素F2α对小鼠FVP诱导的红细胞生成具有相似作用,且前列腺素F2α的作用是间接的。EIF和前列腺素F2α作用的相似性可能表明前列腺素在某些类型红细胞增多症的生理调控中具有潜在作用。

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