外渗性癌症化疗药物引起的软组织坏死。
Soft-tissue necrosis induced by extravasated cancer chemotherapeutic agents.
作者信息
Barr R D, Benton S G, Belbeck L W
出版信息
J Natl Cancer Inst. 1981 Jun;66(6):1129-36. doi: 10.1093/jnci/66.6.1129.
PMID:6941044
Abstract
The inadvertent extravasation of anticancer drugs in clinical use may result in the development of indolent lesions at the site of injection. Investigation of this phenomenon in Hartley guinea pigs showed that the pathogenesis was based on direct tissue toxicity and not on sensitization. The risk of a serious reaction appeared to be related to the localization of the injurious agent within the dermis rather than at the subcutaneous site.
摘要
临床使用中抗癌药物的意外外渗可能导致注射部位出现惰性病变。在哈特利豚鼠身上对这一现象的研究表明，其发病机制基于直接的组织毒性而非致敏作用。严重反应的风险似乎与损伤剂在真皮内的定位有关，而非皮下部位。
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