Tchernitchin A, Wenk E J, Southren A L, Vittek J
J Dent Res. 1980 Dec;59(12):2100-3. doi: 10.1177/00220345800590121401.
The localization of 3H-dexamethasone in gingiva and in buccal mucosa was investigated radioautographically after systemic administration of the labeled glucocorticoid to rabbits. Tissue samples were processed for dry radioautography of diffusible substances. This study demonstrates localization of 3H-dexamethasone in the nuclei of target cells in the gingival epithelium, stromata, and the walls of blood vessels, and to a lesser degree in the buccal mucosa cells. The findings support the possibility of a direct effect of glucocorticoids via specific hormone cytosol-nuclear receptors in oral tissues.
在给兔子全身注射标记的糖皮质激素后，通过放射自显影术研究了3H-地塞米松在牙龈和颊黏膜中的定位。对组织样本进行处理，以进行可扩散物质的干放射自显影。本研究表明，3H-地塞米松定位于牙龈上皮、基质和血管壁的靶细胞核中，在颊黏膜细胞中的定位程度较低。这些发现支持了糖皮质激素通过口腔组织中特定的激素胞质-核受体产生直接作用的可能性。
