Gaffar A, Niles H P, Davis C B
J Dent Res. 1981 Aug;60(8):1432-9. doi: 10.1177/00220345810600080701.
A low molecular weight oligomer of sulfoacrylic acid (ND-2) was effective in inhibiting hydroxyapatite formation in vitro at 33 ppm from a saturated solution of calcium and phosphate. The oligomer did not damage or etch human dental enamel in vitro at pH 5.0 and 7.5. It significantly reduced calculus formation when applied topically in beagles at a concentration of 1% in a rinse. In a second study using 30 beagle dogs, the rinses containing 0.1% CPC and 0.1% CPC + 2% ND-2 significantly reduced (alpha less than 0.05) plaque and gingivitis for 12 wk when compared to a placebo rinse. One-tenth percent CPC rinse induced more discoloration of teeth than the placebo, while the rinse containing 0.1% CPC + 2% ND-2 had significantly less discoloration than CPC rinse or the placebo rinse in beagles. Thus the oligomer was effective in reducing CPC-induced discoloration in beagles.
低分子量磺基丙烯酸低聚物（ND - 2）在体外能有效抑制羟基磷灰石形成，在钙和磷酸盐饱和溶液中，其浓度为33 ppm时即可发挥作用。该低聚物在体外pH值为5.0和7.5的条件下不会损害或侵蚀人类牙釉质。在比格犬身上局部应用浓度为1%的含漱液时，它能显著减少牙结石的形成。在第二项使用30只比格犬的研究中，与安慰剂含漱液相比，含有0.1%西吡氯铵（CPC）和0.1% CPC + 2% ND - 2的含漱液在12周内可显著减少（α<0.05）牙菌斑和牙龈炎。0.1% CPC含漱液比安慰剂导致牙齿变色更严重，而含有0.1% CPC + 2% ND - 2的含漱液在比格犬中引起的变色明显少于CPC含漱液或安慰剂含漱液。因此，该低聚物在减少比格犬中CPC引起的牙齿变色方面是有效的。
