Takeda M, Gomi K, Lewis P L, Tamura K, Ohoki S, Fujimoto Y, Kikyo S
Acta Cytol. 1981 May-Jun;25(3):229-36.
A study was made of 119 case of early gastric carcinomas as to age, sex, histologic cell types, depth of penetration of the cancer, metastasis to the regional lymph nodes and cellular changes of the mucosa near the foci of center. Two distinctly different cellular types were identified. One was the intestinal type, and the other was a diffusely infiltrated, mixed-cell type that was termed the "gastric" type. In both sexes, the intestinal type occurred in the older age group while the gastric type was noted in the younger age group. Once the cancer had penetrated through the muscularis mucosae, there was a sudden, increased incidence of metastasis to the regional lymph nodes regardless of the cellular type. While still confined to the mucosae, only one case of early gastric carcinoma, one of the gastric type, had metastasized to the regional lymph nodes. On this histologic basis, cytologic characteristics of two types of gastric carcinoma are summarized, and the importance of their recognition is emphasized.
对119例早期胃癌患者进行了研究，内容涉及年龄、性别、组织学细胞类型、癌的浸润深度、区域淋巴结转移以及病灶中心附近黏膜的细胞变化。确定了两种明显不同的细胞类型。一种是肠型，另一种是弥漫浸润的混合细胞型，称为“胃”型。在男女两性中，肠型多见于老年组，而胃型多见于青年组。一旦癌穿透黏膜肌层，无论细胞类型如何，区域淋巴结转移的发生率都会突然增加。当癌仍局限于黏膜时，仅1例早期胃癌（胃型）发生了区域淋巴结转移。在此组织学基础上，总结了两种类型胃癌的细胞学特征，并强调了识别它们的重要性。
