一名急性粒单核细胞白血病患者发生白色念珠菌引起的椎间盘间隙感染和骨髓炎。

Vertebral disc space infection and osteomyelitis due to Candida albicans in a patient with acute myelomonocytic leukemia.

作者信息

Shaikh B S, Appelbaum P C, Aber R C

出版信息

Cancer. 1980 Mar 1;45(5):1025-8. doi: 10.1002/1097-0142(19800301)45:5<1025::aid-cncr2820450532>3.0.co;2-i.

DOI:10.1002/1097-0142(19800301)45:5<1025::aid-cncr2820450532>3.0.co;2-i

Abstract

A 67-year old man with acute myelomonocytic leukemia had Candida albicans fungemia during induction chemotherapy. Bilateral pulmonary infiltrates and hepatic granulomata containing yeast forms and septate hyphae developed, but cultures of the hepatic tissue failed to grow a fungus. Although his pulmonary and liver disease improved following appropriate therapy, vertebral osteomyelitis due to Candida albicans developed approximately 12-15 weeks after the original fungemia. The fungal osteomyelitis was successfully treated with amphotericin B and 5-fluorocytosine. This case illustrates the need for early diagnosis and aggressive treatment of fungal infections in patients with leukemia.

摘要

一名67岁的急性粒单核细胞白血病男性患者在诱导化疗期间发生了白色念珠菌菌血症。出现了双侧肺部浸润以及含有酵母形式和分隔菌丝的肝脏肉芽肿，但肝脏组织培养未能培养出真菌。尽管经过适当治疗后他的肺部和肝脏疾病有所改善，但在最初的菌血症发生约12 - 15周后，出现了由白色念珠菌引起的脊椎骨髓炎。真菌性骨髓炎通过两性霉素B和5-氟胞嘧啶成功治愈。该病例说明了白血病患者真菌感染早期诊断和积极治疗的必要性。