Børresen A L, Berg K, Magnus P
Clin Genet. 1981 Apr;19(4):281-9. doi: 10.1111/j.1399-0004.1981.tb00710.x.
Aryl hydrocarbon hydroxylase (AHH) inducibility was studied in cultured lymphocytes from 28 monozygotic (MZ) and 19 dizygotic (DZ) twin pairs. The results indicate that the induced level of AHH activity as well as inducibility (expressed as the ratio between levels in induced and non-induced cells) are inherited. The best (h2) estimate of heritability is 0.7. There was no suggestion that non-induced AHH activity level is an inherited trait. Inducibility of AHH was not normally distributed and the distribution observed in this limited series might even be trimodal. The results of the study appear to confirm previous reports that AHH inducibility is an inherited trait, and do not exclude the possibility that the major part of the variation is controlled by one locus.
在来自28对同卵（MZ）双胞胎和19对异卵（DZ）双胞胎的培养淋巴细胞中研究了芳烃羟化酶（AHH）的诱导性。结果表明，AHH活性的诱导水平以及诱导性（表示为诱导细胞和未诱导细胞中水平的比率）是可遗传的。遗传性的最佳（h2）估计值为0.7。没有迹象表明未诱导的AHH活性水平是一种遗传性状。AHH的诱导性并非呈正态分布，在这个有限系列中观察到的分布甚至可能是三峰的。该研究结果似乎证实了先前的报道，即AHH诱导性是一种遗传性状，并且不排除大部分变异由一个基因座控制的可能性。
