Comparison of nuclear proteins of differentiation-induced and uninduced Friend erythroleukemia cells.

Nuclear non-histone protein content decreased to about 50% during the course of differentiation of Friend cells (Morioka, K., Tanaka K, & Ono, T. (1980) J. Biochem. 88 517-524). Judging from the patterns of Coomassie blue staining after SDS-polyacrylamide gel electrophoresis, the contents of non-histone proteins generally decreased, except for a few proteins such as IP25, while no marked change was observed in histones during differentiation.