Orzechowska-Juzwenko K
Pol J Pharmacol Pharm. 1980 May-Jun;32(3):271-80.
The influence of busulphan and chlorambucil on the activity of the alkaline and acid phosphatase, alpha-naphtol-acetate esterase, the content of glycogen and lipids in leukocytes of peripheral blood in patients with chronic granulocytic and lymphatic leukemia was investigated. Under the influence of both antileukemic drugs some cytochemical reactions typically changed in leukemia were progressively normalized before remission being sometimes more distinctive than leukocytosis or even than white blood picture. In patients who did not show any improvement the disturbance of cytochemical reactions in leukocytes intensified or, sometimes, remain unchanged. The characteristic feature of the changes of cytochemical reactions during chemotherapy may be used for a better control of the treatment, for estimation of the efficiency of a therapy and can give some prognostic suggestions.
研究了白消安和苯丁酸氮芥对慢性粒细胞性白血病和淋巴细胞性白血病患者外周血白细胞中碱性磷酸酶、酸性磷酸酶、α-萘酚醋酸酯酶的活性以及糖原和脂质含量的影响。在这两种抗白血病药物的作用下，白血病中一些典型的细胞化学反应在缓解前逐渐恢复正常，有时比白细胞增多甚至比血象变化更明显。在没有任何改善的患者中，白细胞中细胞化学反应的紊乱加剧，有时保持不变。化疗期间细胞化学反应变化的特征可用于更好地控制治疗、评估治疗效果，并能提供一些预后建议。
