Abnormal prostaglandin excretion in children with minimal change nephrotic syndrome.

In children in the acute phase of steady state edema in minimal change nephrotic syndrome renal prostaglandin synthesis as determined by urinary PGE2 and PGE2alpha excretion was evaluated. Age matched healthy children served as controls. In our patients highly significantly increased PGF2alpha excretion accompanied by high urinary aldosterone excretion with normal PGE2 were found. It is possible that abnormal prostaglandin synthesis within the kidney may play a role in pathogenesis of minimal change nephrotic syndrome.