急性髓性白血病患者皮下注射阿糖胞苷的药代动力学
The pharmacokinetics of subcutaneous cytosine arabinoside in patients with acute myelogenous leukaemia.
作者信息
Slevin M L, Piall E M, Aherne G W, Johnston A, Sweatman M C, Lister T A
出版信息
Br J Clin Pharmacol. 1981 Oct;12(4):507-10. doi: 10.1111/j.1365-2125.1981.tb01258.x.
Abstract
1 The pharmacokinetics of subcutaneous cytosine arabinoside were compared with bolus intravenous injection and intravenous infusion in five patients with acute myelogenous leukaemia. 2 Subcutaneous cytosine arabinoside was rapidly absorbed and then declined biexponentially with initial and terminal half-lives similar to intravenous bolus injection. 3 Cytosine arabinoside levels declined rapidly after intravenous bolus and subcutaneous bolus injection, and fell below steady state infusion levels after a mean time of 40 min (intravenous bolus) and 100 min (subcutaneous injection).
摘要
- 对5例急性髓性白血病患者皮下注射阿糖胞苷的药代动力学与静脉推注及静脉输注进行了比较。2. 皮下注射阿糖胞苷吸收迅速，随后呈双指数下降，初始半衰期和终末半衰期与静脉推注相似。3. 静脉推注和皮下推注后阿糖胞苷水平迅速下降，平均40分钟（静脉推注）和100分钟（皮下注射）后降至稳态输注水平以下。
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本文引用的文献
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STRIPACT, an interactive curve fit programme for pharmacokinetic analyses.STRIPACT，一款用于药代动力学分析的交互式曲线拟合程序。
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Extraction and analytic procedures for cytosine arabinoside and 1-beta-D-arabinofuranosyluracil and their 5'-mono-, di-, and tri-phosphates.
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