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东部肿瘤协作组关于成人急性髓系白血病细胞化学的研究:亚型与反应及生存的相关性

Eastern Cooperative Oncology Group study of the cytochemistry of adult acute myeloid leukemia by correlation of subtypes with response and survival.

作者信息

Bennett J M, Begg C B

出版信息

Cancer Res. 1981 Nov;41(11 Pt 2):4833-7.

PMID:6945906
Abstract

A study of over 300 adult patients with acute myeloid leukemia has been completed by member institutions of the Eastern Cooperative Oncology Group. A complete remission rate of 51% was achieved. The FAB classification was used with an overall concordance of 61% between investigators and the repository center. Acute monocytic leukemia (M5) and acute erythroleukemia (M6) accounted for 12% of the cases accessioned and had the worst median survival with no patients surviving 2 years. The longest response duration occurred in hypergranular promyelocytic leukemia (M3).

摘要

东部肿瘤协作组的成员机构完成了一项针对300多名成年急性髓系白血病患者的研究。完全缓解率达到了51%。采用了FAB分类法,研究者与储存中心之间的总体一致性为61%。急性单核细胞白血病(M5)和急性红白血病(M6)占入组病例的12%,其生存期中位数最差,无患者存活超过2年。缓解持续时间最长的是高颗粒早幼粒细胞白血病(M3)。

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