Hartmann F
Int Dent J. 1981 Dec;31(4):273-85.
Corticoids given therapeutically may interrupt the loop on feedback mechanism by which plasma cortisol levels are controlled. This was demonstrated when corticoids were applied to the skin in the treatment of dermatoses and when taken by mouth the patients with polyarthritis. In rats, Endomethasone root fillings has similar effect. Corticoids applied to the gingiva or instilled into periodontal pockets did not lower group mean plasma cortisol levels but individual patients did show suppression of cortisol secretion. It is concluded that all corticoids, no matter how applied, will have this effect, although present analytical methods may be too insensitive to detect the smaller changes.
治疗性给予的皮质类固醇可能会中断控制血浆皮质醇水平的反馈机制循环。这在将皮质类固醇用于治疗皮肤病时涂抹于皮肤以及多关节炎患者口服时得到了证实。在大鼠中，地塞米松根管充填也有类似效果。将皮质类固醇应用于牙龈或注入牙周袋中并未降低组平均血浆皮质醇水平，但个别患者确实出现了皮质醇分泌受抑制的情况。可以得出结论，所有皮质类固醇，无论应用方式如何，都会有这种效果，尽管现有的分析方法可能过于不敏感，无法检测到较小的变化。
