Remagen W, Jani L, Lüthi A, Schuman L
J Cancer Res Clin Oncol. 1981;101(2):177-82. doi: 10.1007/BF00413311.
A bone tumor was detected in the distal right femur of a 15-year-old girl. The age of the patient, the localization, and the X-ray picture were in favor of an osteosarcoma. However, histology was consistent with a "highly differentiated chondrosarcoma with dedifferentiation and focal osteosarcomatous metaplasia". The tumor was resected with preservation of the limb. One year later the tumor recurred, and the leg was exarticulated. Histology was again of the same type, as was the case in a single lung metastasis taken out another half year later. Two series of chemotherapy according to an osteosarcoma protocol had no recognizable effect. An unambiguous diagnosis cannot yet be made.
在一名15岁女孩的右股骨远端检测到骨肿瘤。患者的年龄、肿瘤位置及X光片表现均支持骨肉瘤的诊断。然而，组织学检查结果符合“伴有去分化和局灶性骨肉瘤化生的高分化软骨肉瘤”。该肿瘤通过保肢手术切除。一年后肿瘤复发，遂行截肢手术。组织学检查结果与之前相同，半年后取出的单个肺转移灶的检查结果也是如此。按照骨肉瘤治疗方案进行的两期化疗未见明显效果。目前仍无法做出明确诊断。
