Phillips A D
Scand J Gastroenterol Suppl. 1981;70:65-85.
A great increase in the knowledge of human small intestinal mucosal pathology has resulted from the use of the peroral small intestinal biopsy technique. This paper highlights some different applications of electron microscopy to such biopsy samples in order to obtain diagnostic criteria and to further the understanding of enteric processes in childhood in health and disease. The importance of control data in childhood is emphasized and differences are described between adult and childhood mucosa. The possibilities of quantitative studies at the ultrastructural level and the link between structure and function are demonstrated by studies on microvillous appearance in relation to disaccharidase enzyme levels; the potential for experimental work is shown in studies using tracer molecules to investigate antigen permeability of the small intestine; and finally descriptive observations is highlighted in a section concerned with parasitic, bacterial and viral infections of the small intestine in childhood.
经口小肠活检技术的应用使人类小肠黏膜病理学知识有了大幅增长。本文着重介绍电子显微镜在这类活检样本中的一些不同应用，以便获得诊断标准并进一步了解儿童期健康与疾病状态下的肠道生理过程。强调了儿童对照数据的重要性，并描述了成人与儿童黏膜之间的差异。通过对与双糖酶水平相关的微绒毛外观的研究，展示了超微结构水平定量研究的可能性以及结构与功能之间的联系；利用示踪分子研究小肠抗原通透性的实验研究展示了实验工作的潜力；最后，在关于儿童期小肠寄生虫、细菌和病毒感染的章节中突出了描述性观察结果。
